Zinc induced G 2 / M blockage is p 53 and p 21 dependent in normal 1 human bronchial epithelial cells 2 3 4 Stephen
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چکیده
Zinc induced G2/M blockage is p53 and p21 dependent in normal 1 human bronchial epithelial cells 2 3 4 Stephen H.K. Wong, Rita S.M. Shih, Norberta W. Schoene, and Kai Y. Lei 5 6 Department of Nutrition and Food Science, University of Maryland, 7 College Park, Maryland 20742 8 2 Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition 9 Research Center, Agricultural Research Service, U.S. Department of Agriculture, 10 Beltsville, MD 20705 11 12 Running Title: Zinc induced G2/M arrest is p53 dependent 13 14 Corresponding Author: David K. Y. Lei 15 Department of Nutrition and Food Science 16 College Park, MD 20742 17 0121 Skinner Building 18 Phone: 301-405-2143 19 Fax: 301-314-3313 20 21
منابع مشابه
Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells.
The involvement of p53 and p21 signal pathway in the G2/M cell cycle progression of zinc-supplemented normal human bronchial epithelial (NHBE) cells was examined using the small interferring RNA (siRNA) approach. Cells were cultured for one passage in a different concentration of zinc: <0.4 microM (ZD) as zinc deficient; 4 microM as normal zinc level (ZN) in culture medium; 16 microM (ZA) as no...
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An adequate zinc status is essential for optimal cellular functions and growth. Yet, excessive zinc supplementation can be cytotoxic and can impair cell growth. Gadd45 plays a vital role as cellular stress sensor in the modulation of cell signal transduction in response to stress. The present study was designed to determine the influence of zinc status on Gadd45 expression and cell cycle progre...
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GATA-binding proteins are a subfamily of zinc finger transcription factors with six members (GATA-1-6) that interact with the GATA deoxyribonucleic acid (DNA) sequence. This sequence is found in the regulatory regions of many genes including those encoding T-helper 2 (Th2)-like cytokines, receptors, adhesion molecules and enzymes, which may be important in the pathogenesis of bronchial asthma. ...
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تاریخ انتشار 2008